HYPOXIA-ALTERED CHOLESTEROL HOMEOSTASIS ENHANCES THE EXPRESSION OF INTERFERON-STIMULATED GENES UPON SARS-COV-2 INFECTIONS IN MONOCYTES

Hypoxia-altered cholesterol homeostasis enhances the expression of interferon-stimulated genes upon SARS-CoV-2 infections in monocytes

Hypoxia contributes to numerous pathophysiological conditions including inflammation-associated diseases.We characterized the impact of Power Reclining Loveseat with Console hypoxia on the immunometabolic cross-talk between cholesterol and interferon (IFN) responses.Specifically, hypoxia reduced cholesterol biosynthesis flux and provoked a compensa

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Unambiguous Characterization of p-Cresyl Sulfate, a Protein-Bound Uremic Toxin, as Biomarker of Heart and Kidney Disease

p-Cresyl sulfate is one of the Allen Wrench bound uremic toxins whose level increases in the sera of patients with the severity of chronic kidney disease and is therefore used as a standard for clinical investigations.Our first attempts to obtain p-cresyl sulfate led exclusively to the product of sulfonation of the aromatic ring instead of sulfatio

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Physiologic Response Evaluation of Human Foetal Osteoblast Cells within Engineered 3D-Printed Polylactic Acid Scaffolds

Large bone defect treatments have always been one of the important challenges in clinical practice and created a huge demand for more efficacious regenerative approaches.The bone tissue engineering (BTE) approach offered a new alternative to conventional bone grafts, addressing all clinical needs.Over the past years, BTE research is focused on the

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